Cerebrospinal Fluid Leaks

CSF leaks through the nasal cavities can be post-traumatic, following skull base surgery, or simply spontaneous — the latter being the most common cause. They result from a defect in the skull base, both in the bony and dural planes, that allows CSF to escape outward. With the brain having a communication to the exterior, there is a risk of ascending bacterial meningitis from common nasal cavity organisms.

Clinically they present as loss of a transparent water-like fluid — non-viscous, unilateral, odorless, with a salty taste — and the flow increases when the patient sits up and leans the head forward. They can be continuous or intermittent, present with recurrent meningitis, or with seizures when associated with brain tissue herniated through the defect, forming a meningoencephalocele.

Symptoms

  • Discharge of a transparent, watery fluid through the nose (rhinorrhea), usually from a single nostril
  • Fluid that is odorless, non-viscous and salty in taste
  • Increased flow when sitting up or leaning the head forward
  • Continuous or intermittent episodes
  • Meningitis
  • Seizures when associated with herniated brain tissue (meningoencephalocele)

Diagnosis

  • Multiaxial computed tomography (CT) of the skull base — to localize the bony defect
  • Magnetic resonance imaging (MRI) — to assess the dural defect and detect herniated brain tissue
  • Fluid analysis (beta-2 transferrin) to confirm that it is cerebrospinal fluid, when necessary
  • Complete neurological evaluation

Treatment

With the development of endoscopic endonasal surgery, it is currently the access route of choice for the treatment of this pathology, without the need for craniotomy. The surgery involves localizing the dural defect and interposing multiple layers of tissue to seal the fistulous tract, providing vascularization with a pediculated nasoseptal flap.

Our approach

  • Specific experience in endoscopic endonasal skull base surgery
  • Minimally invasive approach, without craniotomies or external incisions
  • Multilayer reconstruction with a pediculated nasoseptal flap for a durable closure
  • Personalized long-term follow-up with imaging controls
Clinical case

First Case

A 45-year-old patient on chronic treatment for rhinorrhea is diagnosed with a CSF leak through the nasal cavities. Imaging studies do not show the defect in the skull base, so endoscopic endonasal surgery is performed directly to localize the fistulous site and seal it. A small bony and dural defect with spontaneous CSF leakage is located in the roof of the right ethmoid — the most frequently observed site due to the natural weakness of the region. An intracranial dural substitute is interposed, and the defect is then covered with a nasoseptal flap providing vascularization to the skull base reconstruction.

Second Case

A 57-year-old patient with intermittent right-sided CSF loss associated with headache. MRI shows herniation of part of the right temporal lobe toward the sphenoid sinus. Axial CT of the skull base shows a bony defect in the right lateral aspect of the sphenoid, through which the meningoencephalocele responsible for the CSF leak herniates.

Third Case

A 22-year-old patient consults for generalized seizures with no history of fluid loss through the nasal cavities. Imaging studies show a voluminous defect in the left middle cranial fossa with an encephalocele responsible for the seizures. Endoscopic endonasal surgery is performed to resect the meningoencephalocele and reconstruct the skull base. Herniated brain tissue is visualized through a congenital defect in the skull base lateral to the maxillary nerve — known as Sternberg's Canal. Reconstruction is done with a dural substitute and a contralateral nasoseptal flap.

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